Early infection of h.

Science (July 1, 2011)

Infection of the stomach bacterium Helicobacter pylorus provides reliable protection from allergic asthma, immunologists at the University of Zurich have shown in animal models, along with allergy specialists from the University Medical Center University of Johann Gutenberg of Mainz. Their results were published in the magazine

clinical studies confirm the hypothesis recently put forward that the sharp increase in allergic diseases in industrialized countries is associated with the rapid disappearance of the specific microorganisms that inhabit the human body. Allergy, asthma has been on the rise in cheap strattera industrialized countries for decades and actually adopted by the epidemic. The rapid growth of allergic respiratory diseases due to air pollution, smoking, hygiene hypothesis and the widespread use of antibiotics. Hygiene hypothesis argues that modern hygiene measures led to a lack of impact of infectious agents is important for normal maturation of the immune system. In an article published in the magazine

clinical trials, researchers at the University of Zurich and the University Medical Center at the University of Mainz Johann Gutenberg now show that the increase in asthma can be attributed to the specific disappearance of the stomach bacterium

Helicobacter Pylori (H. pylori

) from Western societies. H. pylori

resistant to stomach acid. It is estimated that about half the world's population could be infected by bacteria. The disease often has no symptoms, but under certain conditions can cause gastritis, gastric ulcer and duodenal ulcer and gastric cancer. Thus, H. pylori

often killed antibiotics as a precautionary measure, even if the patient has no complaints. Early infection of H. pylori

protects from asthma for their study, the researchers infected mice with H. pylorus

Bacteria.

When mice were infected at the age of a few days, they have developed immune tolerance to the bacteria and even responded marginally - if at all - strong, causing asthma allergens. Mice that were infected with H.

Pylori, until they reached adulthood, however, were much weaker protection. Early infection affects the maturation of dendritic cells and cause accumulation of regulatory T cells that are crucial for Asthma, says Anne Mller, Professor of Molecular Oncology at the University of Zurich and explain the protective mechanism. If regulatory T cells were transferred from infected to even those not infected mice, they also enjoy effective protection against allergic asthma. However, mice that were infected early and lost their resistance to asthma causing allergens, if H. pylori

killed them with antibiotics after the sensitization phase. For lung and allergy specialist Christian Taube, Senior Physician III. Medical Clinic of the University Johann Gutenberg, Mainz, new results support the hypothesis that the increase in allergic asthma in industrialized countries is associated with widespread use of antibiotics and the subsequent disappearance of bacteria that constantly fill the human body: the study of these fundamental mechanisms is extremely important for us to understand asthma and be able to develop preventive and therapeutic strategies in the future. Recommend this story on Facebook, Twitter

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and Google +1: Other Bookmark and collaboration: History Source: above story with materials provided. Note: materials may be edited for content and length. For more information, please contact the source listed above. Journal Links Isabelle S. Arnold, Nina Dehzad, Sebastian Reuter, Helen Martin, Burkhard Becher, Christian Taube, Anne Mller. Helicobacter infection prevents allergic asthma in mice by inducing regulatory T cells. Journal of Clinical Investigation, Vol. 121, № 8 DOI:

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